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Fig. 3. Reduced sarcolemmal integrity in muscle from mdx/ ${alpha}$ 7^-/- mice. (A) Evan's Blue dye (EBD) uptake was used to assess membrane integrity of the tibialis anterior skeletal muscle. Myofibers were outlined with Oregon Green-488-conjugated WGA (green). EBD uptake (red) was not detected in wild-type and ${alpha}$ 7^-/- myofibers. By contrast, significant EBD uptake was observed in muscle from mdx and mdx/ ${alpha}$ 7^-/- animals. Bar, 10 µm. (B) The number of EBD-positive muscle fibers was assayed. Wild-type and ${alpha}$ 7^-/- muscle had less than 1% EBD-positive fibers. By contrast, 18.9% of fibers were positive for EBD in mdx/ ${alpha}$ 7^-/- mice, but this was not significantly different from the number of EBD-positive fibers seen in mdx animals.

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