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Figure 5


Fig. 5. Enhanced myofiber regeneration in mdx/{alpha}7-/- mice. (A) Hematoxylin and eosin staining of tibialis anterior muscle of 3-week-old mice to analyze the localization of nuclei within myofibers. Centrally localized nuclei were observed in the muscle of mdx/{alpha}7-/- mice. Compared with control genotypes they indicate extensive muscle regeneration, which follows degeneration of diseased myofibers. Central nuclei are indicated by arrows. Bar, 10 µm. (B) Quantitation of centrally-located nuclei in triceps and tibialis anterior muscles. As expected, wild-type mice exhibited peripherally located nuclei in both muscle groups. Centrally located nuclei were observed in muscle fibers from mdx and {alpha}7-/- mice compared with wild-type (2.8% and 0.32%, respectively, for triceps muscle; 4.1% and 3.2%, respectively, for tibialis anterior muscle). By contrast, mdx/{alpha}7-/- mice showed 40.1% and 17.5% centrally located nuclei in triceps and tibialis anterior muscle, respectively, which are significantly higher than controls (*P<0.05).





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