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Fig. 7. Altered expression of laminin- ${alpha}$ 2 chain in the skeletal muscle of mdx/ ${alpha}$ 7^-/- mice. (A) Immunofluorescence was used to detect the localization of ß1D and laminin- ${alpha}$ 2 chain in triceps muscle of 3-week-old mice. A similar pattern of ß1D localization at the myofiber sarcolemma was observed in wild-type, ${alpha}$ 7^-/-, mdx and mdx/ ${alpha}$ 7^-/- mice. Immunofluorescence revealed a decrease in laminin- ${alpha}$ 2 chain in the muscle of ${alpha}$ 7^-/- and mdx/ ${alpha}$ 7^-/- mice compared with both wild-type and mdx mice. Bar, 10 µm. (B) Laminin- ${alpha}$ 2 expression in the gastrocnemius muscle was quantitated by western analysis. mdx mice showed a significant increase in laminin- ${alpha}$ 2 expression compared with wild-type. ${alpha}$ 7^-/- and mdx/ ${alpha}$ 7^-/- mice showed a decrease in laminin- ${alpha}$ 2-chain expression compared with wild-type and mdx animals (^*P<0.05).

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