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Fig. 8. Increased utrophin expression in mdx but not mdx/ ${alpha}$ 7^-/- mice. (A) Utrophin localization was examined by immunofluorescence in the gastrocnemius muscle of 3-week-old wild-type, mdx, ${alpha}$ 7^-/- and mdx/ ${alpha}$ 7^-/- mice. As expected, utrophin was localized at the NMJs of muscle from wild-type mice and at neuromuscular and extrajunctional sites of muscle from mdx animals, confirming previous studies. Utrophin localization appeared at both junctional and extrajunctional sites in ${alpha}$ 7^-/- or mdx/ ${alpha}$ 7^-/- mice. Bar, 10 µm. (B) Utrophin expression in the gastrocnemius muscle was quantitated by western analysis. mdx mice showed a statistically significant increase in utrophin expression compared with wild-type (^*P<0.05). ${alpha}$ 7^-/- and mdx/ ${alpha}$ 7^-/- mice showed no increase in utrophin compared with wild-type animals.

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