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Fig. 4. Voltage-dependent gating of wild-type (wt) and mutant connexin channels expressed in N2a (A-E) or in HeLa (F) cells. The relationships between normalized steady-state conductance (G_j) and transjunctional voltage (V_j) are shown for cell pairs expressing (A) wtCx40 (stably)-wtCx40 (stably), (B) wtCx43 (stably)-wtCx43 (stably), (C) Cx40E12S,E13G (transiently)-Cx40E12S,E13G (transiently), (D) Cx43D12S,K13G (transiently)-Cx43D12S,K13G (transiently), (E) the heterotypic combination Cx40E12S,E13G (transiently)-wtCx40 (stably), and (F) the heterotypic combination Cx43D12S,K13G (transiently)-wtCx43 (stably). The mathematical fits to the G_j-V_j relationships are described in Tables 2 and 3. All normalized data represent the mean values from 4-6 experiments.

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