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Figure 8


Fig. 8. Addition of a ß1-integrin-activating antibody, 9EG7, rescues cells from apoptosis as a result of MLCK or actin polymerization inhibition. MCF-10A (A) and MCF-10A Ras-transformed (B) cells were plated with 20 µg/ml 9EG7 for 24 hours and subsequently treated with ML-7, ML-9 and LA. (C) Phospho-FAK is decreased in cells treated with inhibitors, and restored in MCF-10A and MCF-10A Ras cells pre-treated with 9EG7, then incubated with Blebbistatin (BB), LA or ML-7 for 1 hour. Total FAK levels remain the same in each cell line with treatments (C).





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