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Figure 4


Fig. 4. Time-lapse imaging reveals that simultaneous RNAi of orbit and Klp10A rescues spindle bipolarity by preventing spindle collapse. (A,B) Selected frames from time-lapse sequences of cells depleted of both Orbit and Klp10A. Time is in seconds relative to prometaphase onset. Unlike in cells downregulated for either Orbit or Klp10A alone, the separation distance between the centrosomes at prophase remains constant or increases during spindle formation. Note the large variation in time needed for anaphase onset between the double-knockdown cells. See text for details. (C) Kinetic profiles of centrosome separation for the cells shown in Fig. 3 and Fig. 4A. Prometaphase onset occurs at 0 seconds. Bars, 10 µm.





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