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Figure 3


Fig. 3. Effects of apoptosis on centrosome integrity. (A) Confocal maximum projections of viable and apoptotic cells transiently expressing GFP-Centrin 2 and subsequently labelled with antibodies against {gamma}-tubulin, ninein or pericentrin. In each zoomed panel to the right of the main image, GFP-centrin labelling is to the top, {gamma}-tubulin, ninein or pericentrin in the middle, with the merged image in the bottom panel. Bars, 5 µm. (B) Cartoon showing the relative locations of each of the centrosomal markers in A, adapted from Bornens (Bornens, 2002) with permission. The grey region around the centrioles represents the pericentriolar space. (C) Quantification of the mean percentage (± s.e.m.) of apoptotic HeLa cells (UV treated) positive for {gamma}-tubulin labelling. Apoptosis stage was determined using the morphological criteria described in Fig. 2.





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