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First published online June 8, 2006

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Macrophage contact soothes muscles

Stromal cells help specialized cells such as those in muscle to grow, develop and survive. This supportive role is poorly understood, however. Bénédicte Chazaud and co-workers have therefore been investigating how macrophages - a recognized stromal cell type - support post-injury muscle regeneration. They report on p. 2497 that macrophages use a set of pro-survival cell-cell adhesion systems to rescue myoblasts and myotubes from apoptosis during this process. The authors show that entry of macrophages into regenerating mouse muscle in vivo correlates with decreased apoptosis of myogenic cells. They then demonstrate that direct cell-cell contact with human macrophages rescues these cells from apoptosis in vitro. Array analysis indicates that macrophages and myogenic cells express the ligands and receptors, respectively, for four pro-survival cell-cell adhesion systems (VCAM-1-VLA-4, ICAM-1-LFA-1, PECAM-1-PECAM-1 and CX3CL1-CX3CR1); experiments with blocking antibodies demonstrate that macrophages use all these to prevent apoptosis of myogenic cells. These results provide new insights into how stromal cells support specialized cells during tissue repair and suggest ways to improve myoblast transfer therapy, which is currently limited by massive cell death.

Related articles in JCS:

Human macrophages rescue myoblasts and myotubes from apoptosis through a set of adhesion molecular systems

C. Sonnet, P. Lafuste, L. Arnold, M. Brigitte, F. Poron, F. Authier, F. Chrétien, R. K. Gherardi, and B. Chazaud
JCS 2006 119: 2497-2507. [Abstract] [Full Text]  

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in JCS Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content