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Figure 2


Fig. 2. Mouse E-cadherin functions as a cell adhesion molecule in Drosophila. cl-8 cells and cl8mEcad cells induced to express high levels of E-cadherin by addition of Cu2+ to the medium, were stained for E-cadherin (A), Arm (B) and {alpha}-catenin (C). In cl-8 cells, mouse E-cadherin was not expressed and Arm and {alpha}-catenin were barely detectable by immunofluorescence. In cl8mEcad cells, all three proteins were highly concentrated at cell-cell contacts. Note that {alpha}-catenin staining was strongly increased in cl8mEcad cells although the total amount of {alpha}-catenin was increased only twofold. This finding can be explained by the diffuse, mostly cytosolic localization of {alpha}-catenin in cl-8 cells (see Fig. 1C), which leads to a very weak immunofluorescence signal.





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