spacer gif spacer gif spacer gif spacer gif spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents    

Right arrow Help viewing high resolution images
Right arrow Return to article
(Downloading may take up to 30 seconds.
If the slide opens in your browser, select File -> Save As to save it.)
Click on image to view larger version.


Figure 5


Fig. 5. FISH analysis of Atmnd1 mutants reveals defects in pairing and chromosome disjunction. Preparations of wild-type (A-C) and Atmnd1 (D-F) meiocytes were hybridised with FISH probes directed against an interstitial region of chromosome 1 (BAC F1N21, green) and a sub-telomeric region of chromosome 2 (BAC F11L15, red). (A,D) Zygotene stage, showing consistent association of sub-telomeric regions in wild-type and occasional association in Atmnd1 cells. (B) Wild-type pachytene/diplotene transition with paired FISH probes. (E) Atmnd1 pachytene-like stage with unpaired FISH signals. (C,F) Anaphase I with a regular distribution of chromosomes and FISH signals in wild-type meiocytes, as opposed to the irregular chromosome disjunction and DNA fragmentation in Atmnd1 cells. Chromosomes are stained with DAPI. Bar, 10 µm.





Right arrow Return to article