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Fig. 2. Ferlin C2 domain phylogeny. A summary phylogenetic tree of C2 domain sequences of one representative ferlin from each species and several other C2 domain-containing proteins is shown. The tree is based on neighbor-joining of C2 domains aligned using ClustalW and refined by hand. Ferlin C2 domains are colored as in Fig. 1, based on their position. The tree shows that the C2 domains with the same color cluster together indicating they are most similar to each other. Non-ferlin C2 domain sequences were previously analyzed by Nalfeski and Falke (Nalfeski and Falke, 1996) (black lines). Bootstrap support indicated along branches for major clades; asterisk (*) indicates <50%. Similar results were obtained with maximum parsimony analysis. Abbreviations: PLCs, phospholipases; Rabs, rabphilins; synapt, synaptotagmins; PKCs, protein kinase C. Additional sequences, together with the individual protein names, are included in supplementary material Fig. S2.
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