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Figure 5


Fig. 5. Conservation of the p75-binding domain in JPO2 among mammalian and avian species. Sequence alignment of the p75-binding domain (human residues 58-128) among known JPO2 orthologs. Amino acids identical in all species are highlighted in red, and sequence identity in at least 70% of the species as well as conservative amino acid substitutions are in yellow. Predicted secondary structural elements ({alpha}-helices, wavy lines; ß-strands, arrows) are shown at the bottom; the minimal binding region identified in Fig. 4 is indicated. Numbering on the top of the alignment corresponds to the human sequence. Accession numbers for JPO2 orthologs are: chimpanzee (Pan troglodytes), XP 527681; mouse (Mus musculus), NP 666152; rat (Rattus norvegicus), NP 001030125; cow (Bos taurus), XP 592513; dog (Canis familiaris), XP 539464; chicken (Gallus gallus), NP 001026153. The alignment was created using ESPript (Gouet et al., 1999).





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