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Figure 1


Fig. 1. Cis-acting sequences that control splicing. (A) Consensus sequences for the 5' splice site (donor), branch site and 3' splice site (acceptor). (B) Arrangement of donor (D) and acceptor (A) sites in the architecture of a typical eukaryotic gene. Whereas internal exons are limited by acceptor and donor sites, the first exon is limited by the Cap site and a donor, and the last exon is limited by an acceptor and the poly(A) site. (C) Examples of sequences for strong and weak acceptor sites. Red indicates the 3' acceptor splice site; bold indicates deviations from the consensus sequence. (D) Schematic roles of exonic splicing enhancers (ESE), exonic splicing silencers (ESS), intronic splicing enhancers (ISE) and intronic splicing silencers (ISS) on the recognition of a weak acceptor by the splicing machinery; red indicates enhancing, blue indicates silencing. In A-D, exon sequences are boxed.





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