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Figure 2


Fig. 2. (A) Different modes of alternative splicing. (B) Alternative promoters provoke mRNA diversity but do not necessarily imply alternative splicing. There are two alternative promoters, P1 and P2. If promoter P2 is used, exons 2, 3 and 4 are constitutively included. If promoter P1 is used, exon 2 simply does not exist for the splicing machinery because, being a 5' terminal exon of the P1 transcription unit, it lacks an upstream 3' splice site. Therefore, the splicing machinery has no option but to join exon 1 directly to exon 3, generating a 1-3-4 mRNA.





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