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Figure 6


Fig. 6. Reduced expression of revertant dystrophin in irradiated mdx muscles. (A) Mice were irradiated at the age of 3 weeks with 4 Gy, 10 Gy, or 18 Gy, and sacrificed at 3 months after the irradiation. The irradiated muscles show reduced number of RFs compared with untreated control mdx muscle (A), suggesting that muscle regeneration is crucial for RF expansion. (B) The number of RF clusters, total number of RFs, and maximal number of RFs in one cluster in mdx TA muscle at 4 weeks after irradiation at 3 weeks of age. The mice were irradiated with 4 Gy (gray bars), 10 Gy (dashed bars) or 18 Gy (white bars), or were non-irradiated (black bars). (C) Comparison of the level of suppression of RF expansion at 1 month or 1 year after 18 Gy irradiation at the age of 3 weeks. Black bars, non-irradiated muscles; white bars, irradiated muscles. Each point is the mean ± s.e.m. of 3-8 muscles per group. *Significant difference (P<0.05) from mdx muscles of the same age. Bar, 100 µm.





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