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Figure 1


Fig. 1. The dose-dependent effects of SMase on CV fusion. (a) Ca2+-activity curves at 0 (n=15), 1 (n=7), 10 (n=15) and 20 U/ml SMase (n=5). Vertical dotted lines indicate the EC50 of each curve (P<0.05). (b) Kinetics of CV fusion triggered with 78.2±5.4 µM [Ca2+]free after treatment with 0, 1 and 20 U/ml SMase (n=5); symbols are as for a. (c) Changes in CV sphingomyelin relative to untreated controls (n=3) after exposure to 1, 5 and 10 U/ml of SMase. *Significant difference from control (P<0.05); **significant difference from control and previous conditions (P<0.001).





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