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Figure 3


Fig. 3. Effects of SMase and mßcd on CV fusion and Cer concentration. (a) Ca2+-activity curves following treatments with mßcd (2 mM) before and after CV exposure to SMase (10 U/ml). Vertical dotted lines indicate the EC50 of each curve. (b) Kinetics of CV fusion triggered with 82.5±4.1 µM [Ca2+]free after treatment with mßcd and/or SMase, as indicated (n=5); symbols are as for a. (c) Total CV ceramide assayed after SMase treatments ± exposure to mßcd (mbcd; 2 mM), as indicated (n=2). *Significant difference from control and the mßcd + SMase treatment (P<0.01).





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