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Figure 8


Fig. 8. Novel concept of chemoprevention of tumor progression. Tumor cells release growth factors and cytokines, e.g. TGFß1, which initiate ROS-dependent changes of gene expression in stromal cells through receptors, resulting in transdifferentiation and release of proinvasive signals. Proinvasive signals stimulate the invasive capacity of cancer cells. These signals are lowered or prevented by treatment of stromal cells with antioxidants and/or micronutrients, finally preventing the generation of tumor-educated myofibroblasts and leading to attenuation of tumor invasion.





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