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Figure 5


Fig. 5. Rac1/2–/– BMMs have altered migratory properties. (A) Cell migration was followed by time-lapse microscopy for 6.5 hours. Migration tracks of cells that moved more than 30 µm from their origin are shown in the vector plots. The origin of each cell is at the intersection of the x and y axis. (B) Quantification of macrophage displacement (net distance moved from origin). The percentage of Wt, Rac2–/– and Rac1/2–/– BMMs that had moved the indicated distance (displacement) from their origin after 6.5 hours is shown. (C) Graph showing the directional persistence (track length/displacement) of Wt, Rac2–/– and Rac1/2–/– BMMs. *P<0.05 vs Wt BMMs (Student's t-test). Data are pooled from three independent experiments; n=120 cells for each genotype. (D-F) Representative phase-contrast images from time-lapse movies of (D) Wt, (E) Rac2–/–, (F) Rac1/2–/– BMMs; elapsed time is indicated in minutes.





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