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Figure 2


Fig. 2. Localization of +TIPs following siRNA-mediated depletion of lamin A/C, p150Glued, EB1 or CLIP-170. (A) RNAi-mediated depletion of p150Glued, EB1 or CLIP-170 all cause a loss of p150Glued from MT plus-ends. Lamin A/C depletion does not affect the localization of p150Glued to MT plus-ends. (B) Enlargements of the boxed regions from (A). (C) Depletion of lamin A/C or CLIP-170 does not affect the localization of EB1. (D) Depletion of EB1 causes a loss of CLIP-170 localization to MT plus-ends. Boxed regions in C and D are shown magnified in the right bottom corner of the images. Bars, 10 µm.





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