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Figure 1


Fig. 1. Aggrecan and Nogo affect axon assembly from adult DRG neurons differently in the presence of extracellular axon promoting factors. (A) When adult DRG neurons (both naive and PCL neurons) were cultured on laminin (LM), treatment with the CNS myelin inhibitor Nogo had no effect on axon assembly. (B) NGF-induced axon assembly from adult naive DRG neurons plated on laminin was markedly inhibited by aggrecan. (C,D) Quantification of the inhibitory effect of aggrecan (Agg.) on axon assembly from adult naive neurons (C) and PCL neurons (D). Values are means ± s.e.m. *P<0.0001 compared with levels in the control. Magnification, 4x.





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