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First published online July 5, 2006

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Yeast spores heed SINful message

During mitosis in fission yeast, a septum forms to separate the newly replicated copies of the genome. Formation of this structure, which is coordinated with the nuclear cycle, is triggered by the septation initiation network (SIN). When starved, fission yeast change to meiotic division to form spores. Here, a forespore membrane, which is organized by the spindle pole body, separates the four haploid nuclei rather than a septum. Viesturs Simanis and colleagues now report that the SIN is also required for forespore membrane formation and subsequent spore formation (see p. 2882). The authors show that meiosis is normal in SIN mutants but, although forespore formation is initiated, the spores do not encapsulate properly. In addition, they report that SIN components localize to the spindle pole body during meiosis as they do during mitosis; all the components necessary for SIN activation are not present until meiosis II, when the forespore membrane begins to form. Thus, the authors conclude, the important compartmentalization processes that occur during mitosis and meiosis are both regulated by SIN signalling.

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Related articles in JCS:

The Schizosaccharomyces pombe septation initiation network (SIN) is required for spore formation in meiosis

Andrea Krapp, Philippe Collin, Adisa Cokoja, Sandra Dischinger, Elena Cano, and Viesturs Simanis
JCS 2006 119: 2882-2891. [Abstract] [Full Text]  

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in JCS Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?