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First published online July 5, 2006

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Dynamin-like protein rules and divides trypanosomes

Dynamins, a family of large modular GTPases, are required for endocytosis whereas dynamin-like proteins (DLPs) generally function in the division of mitochondria and other organelles. Trypanosoma brucei, however, has a single DLP (TbDLP) and no dynamins – so what is the role of the DLP in this parasite? On p. 2968, André Schneider and co-authors report that TbDLP is required for mitochondrial fission, endocytosis and, unexpectedly, the completion of cytokinesis. Previous work indicated that TbDLP is involved in mitochondrial fission but not endocytosis. Schneider and colleagues, however, demonstrate that ablation of TbDLP function by RNAi or expression of a dominant-negative mutant abolishes both these processes. Moreover, they show that TbDLP localizes to both the single mitochondrion of T. brucei and the flagellar pocket, the site where endocytosis occurs in this organism. The authors' final discovery that ablation of TbDLP induces a precise cell-cycle block leads them to suggest that mitochondrial fission is a key event that is monitored by the cytokinesis checkpoint in T. brucei.

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Related articles in JCS:

Ablation of the single dynamin of T. brucei blocks mitochondrial fission and endocytosis and leads to a precise cytokinesis arrest

Anne-Laure Chanez, Adrian B. Hehl, Markus Engstler, and André Schneider
JCS 2006 119: 2968-2974. [Abstract] [Full Text]  

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in JCS Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?