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First published online July 5, 2006

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PDGF signalling: two forms of Src'asm

Src family kinases (SFKs) regulate both mitogenesis and morphological changes induced by platelet-derived growth factor (PDGF). How PDGF uses SFKs to transmit these two very different signals is largely unknown. Now, however, Christine Benistant and colleagues report that two distinct pools of SFKs control PDGF-induced responses in mouse fibroblasts (see p. 2921). The authors first show that caveolae (cholesterol-enriched membrane microdomains) are required for SFK-mediated mitogenic signalling and that caveolae-enriched subcellular membranes regulate the formation of PDGF-receptor–SFK complexes. Then, they identify a second pool of PDGF-activated SFKs, whose activity, unlike that of the caveolae-associated pool, is insensitive to cholesterol depletion. This pool of activated SFKs is required for induction of dorsal ruffles and is regulated by a pathway involving phospholipase C, sphingosine 1-phosphate and the G protein G_i; none of the components of this pathway is involved in the mitogenic response to PDGF. Thus, the authors suggest, PDGF stimulates two spatially distinct pools of SFKs to control DNA synthesis and dorsal ruffle formation.

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Related articles in JCS:

Two distinct pools of Src family tyrosine kinases regulate PDGF-induced DNA synthesis and actin dorsal ruffles

Laurence Veracini, Mélanie Franco, Anthony Boureux, Valérie Simon, Serge Roche, and Christine Benistant
JCS 2006 119: 2921-2934. [Abstract] [Full Text]  

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in JCS Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?