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First published online July 5, 2006

Journal of Cell Science 119, 1403e (2006)
© The Company of Biologists Limited
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In this issue

PDGF signalling: two forms of Src'asm


Figure 1

Src family kinases (SFKs) regulate both mitogenesis and morphological changes induced by platelet-derived growth factor (PDGF). How PDGF uses SFKs to transmit these two very different signals is largely unknown. Now, however, Christine Benistant and colleagues report that two distinct pools of SFKs control PDGF-induced responses in mouse fibroblasts (see p. 2921). The authors first show that caveolae (cholesterol-enriched membrane microdomains) are required for SFK-mediated mitogenic signalling and that caveolae-enriched subcellular membranes regulate the formation of PDGF-receptor–SFK complexes. Then, they identify a second pool of PDGF-activated SFKs, whose activity, unlike that of the caveolae-associated pool, is insensitive to cholesterol depletion. This pool of activated SFKs is required for induction of dorsal ruffles and is regulated by a pathway involving phospholipase C{gamma}, sphingosine 1-phosphate and the G protein Gi; none of the components of this pathway is involved in the mitogenic response to PDGF. Thus, the authors suggest, PDGF stimulates two spatially distinct pools of SFKs to control DNA synthesis and dorsal ruffle formation.


Related articles in JCS:

Two distinct pools of Src family tyrosine kinases regulate PDGF-induced DNA synthesis and actin dorsal ruffles
Laurence Veracini, Mélanie Franco, Anthony Boureux, Valérie Simon, Serge Roche, and Christine Benistant
JCS 2006 119: 2921-2934. [Abstract] [Full Text]  




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