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Figure 2


Fig. 2. Calorie restriction induces cGMP production through an increase in eNOS levels in white adipose tissue and other mouse tissues. Nuclear genes involved in mitochondrial biogenesis, including PGC-1{alpha}, are upregulated as a consequence, leading to increased mitochondrial biogenesis, as well as resistance to stress and diminished fat synthesis, mainly throughout SIRT1 gene expression.





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