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Figure 6


Fig. 6. ROCK-dependent activation of LIMK1 is required for the increase in cofilin phosphorylation following EGF stimulation. (A) MTLn3 cells were preincubated with the ROCK inhibitor Y-27632 (10 µM) for 30 minutes prior to stimulation with EGF. Cell lysates were prepared at 0 and 60 seconds following stimulation with EGF, western blotted and probed with antibodies against p-cofilin and activated p-LIMK. (B,C) Quantification of western blot for changes of LIMK1 and p-cofilin showing the inhibition of LIMK1 and cofilin phosphorylation caused by ROCK inhibitor. (Error bars indicate the s.e.m.)





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