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Fig. 8. Tomosyn-1-silencing affects exocytosis at a step beyond Ca²⁺ influx. (A) Charge/voltage (Q/V) relation recorded in siRNA-i-treated cells (control, gray squares) and siRNA-a treated cells (tomosyn-1-silenced, black circles). (B) Ca²⁺ evoked exocytosis. Left: Mean capacitance increase ( ${Delta}$ C/ ${Delta}$ t) in control (siRNA-i treated cells, gray bar) and tomosyn-1-silenced cells (siRNA-a, black bar). Exocytosis was elicited by intracellular dialysis of a patch pipette solution containing Ca²⁺-EGTA buffer (free [Ca²⁺]_i $~$ 1.5 µM). Right: Examples of capacitance traces from one control and one tomosyn-1-silenced cell (siRNA-a) as indicated. The standard whole-cell configuration was established at t=0, indicated by the arrow. *P<0.05, significantly different (unpaired t-test).

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