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Figure 8


Fig. 8. Abl is an effector of the S1P signalling for PDGF-induced dorsal ruffle formation. (A) Abl, but not other Src mitogenic substrates, is required for PDGF-induced dorsal ruffle formation. PDGF response (percentage of cells with dorsal ruffles) of cells expressing indicated constructs. (B) PDGF-induced Abl but not Stat3 activation requires an S1P signalling pathway. Stat3 was immunoprecipitated from cells treated with the indicated drugs and stimulated or not with PDGF as shown. Abl was detected in the same way as Stat3 and then assayed for in vitro kinase activity. The levels of Stat3 and pY705Stat3 were assessed by western blotting. [32P]Gst-Crk was also detected.





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