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Fig. 4. The second stage of TRPL translocation is induced in darkraised Trp^P365/+ mutants. Shown are representative cross-sections of single ommatidia from dark-raised wild-type (WT) and Trp^P365/+ newly eclosed adult flies (<4 hours old), 18-22 hours after eclosion (AE), and 40-44 hours AE, immunostained for TRPL. Wild-type photoreceptors exhibited rhabdomeric localization of TRPL channels in the dark, regardless of age. Trp^P365/+ flies less than 4 hours old also displayed rhabdomeric TRPL localization, indicating that TRPL channels are initially trafficked to the rhabdomeres similar to wild type. By 18-22 hours AE, TRPL channels in Trp^P365/+ mutants had translocated to the basolateral membrane of photoreceptors. Shown for each genotype are representative ommatidia from multiple retinal tissue sections; wild-type: two eyes of two flies (<4hrs AE), two eyes of two flies (18-22hrs AE), three eyes of two flies (40-44hrs AE); Trp^P365/+: five eyes of five flies (<4hrs AE), five eyes of five flies (18-22hrs AE), six eyes of five flies (40-44hrs AE).

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