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Figure 7


Fig. 7. MTMR4 (C407S) inhibits EGF receptor degradation. HeLa cells were transfected with phosphatase-inactive MTMR4, pHAC407S (A-C), or with an additional point mutation in the FYVE domain HA-C407S/C1169S (D-F). 100 ng/ml EGF was added to starved cells for 4 hours, which were then fixed and processed for immunofluorescence of EGFR as described in Materials and Methods. Bars, 10 µm. Cells expressing MTMR4-C407S but not its FYVE domain mutant retain EGFR in numerous bright fluorescent punctae.





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