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Figure 3


Fig. 3. KCNQ4 and prestin expression in OHCs of TR{alpha}1–/–ß–/– mutants compared with hypothyroidism at P10. (A,B) In OHCs of hypothyroid rats (hypo), prestin is expressed but its immature distribution persists (A, red) whereas KCNQ4 expression is absent (B, red). (C,D) In TR{alpha}1–/–/ß–/– mutants, both prestin (C, red) and KCNQ4 (D, red) are expressed but their immature distribution persists. Double immunohistochemistry was performed with synaptophysin (green). Open arrowheads, basal pole of OHCs; filled arrowheads, KCNQ4 and prestin protein. Bar, 20 µm.





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