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Figure 10


Fig. 10. PMCA2wa apical targeting is not altered by deafwaddler Gly283Ser mutation and is independent of its phospholipid activation site (G domain). (A,B) High-resolution confocal scans of the hair bundles (plane 2 in C, actin in red) and cross-sectional scans of the basolateral PM (plane 3 in C) of HCs expressing mutated variants of PMCA2wa (green) are shown in merged channels. (A) Deafwaddler mouse mutant (Dfw; Gly283Ser) and (B) del12[380-91] mutations are represented in red in the aa sequence of the second cytosolic loop of PMCA2wa, the phospholipids-binding site is underlined (B). Both mutated variants are targeted exclusively apically. TM, Transmembrane domain; n, number of examined transfected hair cells. Bars, 5 µm.





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