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Figure 2


Fig. 2. Characteristic domains of the methyl CpG binding (MBD) protein family. The predominant isoform of MeCP2 expressed in human brain has 498 residues. MBD1 has multiple isoforms, ranging in size from 50 to 70 kDa (605 residues, 586 residues, 556 residues, 549 residues and 503 residues). MBD2 contains 414 residues (44 kDa); MBD3 has two splice variants: 285 residues and 253 residues (27 and 32 kDa, respectively). MBD4 contains 554 residues (63 kDa). The MBD sequence motif is depicted as an orange box in each protein. Other defined sequence motifs in the individual MBD family members are also depicted.





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