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Figure 2


Fig. 2. Subcellular distribution of Kir6.1-SUR2A complexes in the intestinal epithelial barrier. (a) The intestinal mucosa of humans is composed of two types of epithelial cells, the tall columnar absorptive cells (enterocytes) bearing a multitude of microvilli at the apical pole, representing the predominant cell type and the goblet cells (note the mucous droplet produced by a secreting goblet cell, arrowhead). The inner surface of the intestinal villi shows invaginations (large arrows). (b-g) These invaginations can also be identified in immunofluorescence micrographs (arrows). Tight junctions connect adjacent epithelial cells at labelled positions (small arrows in a) and appear as immunolabelled dots in fluorescence microscopy (small arrows in b-d,). Note the precise colocalization of Kir6.1 (green in b) and SUR2A (green in e) with the ZO-1-epitopes (red in c and f,) as identified in the merged photographs (d,g) in orange. Bars, 20 µm.





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