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Fig. 2. Survival response of crest cells to LN-1 and E8 and E1' proteolytic fragments. (A) Survival after 4, 24 and 48 hours of culture on LN-1 and E8 and E1' fragments at 1-100 µg/ml. (B) Survival on native (white symbols) and heat-denatured (black symbols) LN-1 (squares), E1' (circles) and E8 (triangles) at 10 µg/ml. (C) Survival on LN-1 (squares), E1' (circles) and E8 (triangles) in the presence (black symbols) or absence (white symbols) of 5% serum. (D,E) Proportion of apoptotic and proliferating cells on LN-1 (squares), E1' (circles) and E8 (triangles).