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Figure 3


Fig. 3. (A-C) Subnuclear distribution of wild-type and mutant prelamin A. (A) Wild-type EGFP-prelamin A, (B) prenylation-incompetent mutant prelamin A (661C->M) and, (C) step-D-incompetent prelamin-A-EGFP-progerin were transiently expressed in HeLa cells and imaged live (A,C) or after indirect immunofluorescence with anti-prelamin A antibodies (B). Digital images taken by light-microscopy and digital deconvolution are shown.





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