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Figure 1


Fig. 1. Palladin localizes to PDGF-induced membrane ruffles. A7r5 cells were plated on fibronectin overnight and serum-starved for 2 hours prior to growth factor treatment. The addition of PDGF led to the induction of dynamic, actin-based membrane protrusions (indicated by arrows). After fixation, endogenous palladin was detected in these structures by immunofluorescence. Co-labeling with TRITC-phalloidin and polyclonal anti-palladin antibody reveals that palladin co-localizes with filamentous actin in ruffles and along stress fibers. Top: low magnification image. Bottom: high magnification image to show detail. Bar, 10 µm.





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