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Figure 6


Fig. 6. Separase S1126A induces premature loss of sister chromatid cohesion. (A) Interphase FISH images of WT and separase S:A cells 24 hour post-induction. (B) Histograms scoring number of FISH foci per cell showing that separase S:A induces aneuploidy. (C) Metaphase spreads 8 hours post-induction showing separated sister chromatids in a separase S:A cell. (D) Bar graph quantitating the number of metaphase spreads with separated chromatids in WT and separase S:A populations 8 hours post-induction. (E,F) Immunofluorescence analysis of mitotic cells expressing either WT or separase S:A, stained as indicated.





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