spacer gif spacer gif spacer gif spacer gif spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents    

Right arrow Help viewing high resolution images
Right arrow Return to article
(Downloading may take up to 30 seconds.
If the slide opens in your browser, select File -> Save As to save it.)
Click on image to view larger version.


Figure 12


Fig. 12. Schematic representation of the possible role of CK2 in p53-dependent regulation of HIF-1 activity. Under hypoxia, elevated CK2 activity triggers p53 degradation, thus relieving p53 inhibition on HIF-1, leading to active HIF-1. When CK2 is inhibited, p53 is stabilized, competes with HIF-1{alpha} for p300, lowering HIF-1 activity.





Right arrow Return to article