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Figure 6


Fig. 6. Effect of p53 overexpression on HIF-1 and p53 transcriptional activity in HepG2 cells. Cells were incubated for 16 hours under normoxia or hypoxia. Cells were cotransfected with pGL3-6HRE (A) or pG13-Luc (B), p53 expression plasmid or pCMV-myc and pRL. p53 activity is expressed as the ratio of firefly luciferase to Renilla luciferase activity (means ± 1 s.d.; n=3). *P<0.05 and ***P<0.001 vs. normoxia; (**)P<0.01 and (***)P<0.001 vs. hypoxia.





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