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Fig. 11. ET-1 and Ins(1,4,5)P₃ ester both stimulate SCTs that are inhibited by 2-APB. (A) Response of a single ventricular myocyte to continuous superfusion with ET-1 (100 nM). The cell was stimulated with ET-1 following the acquisition of the top (0 seconds) trace. Positive inotropy and SCT frequency developed progressively during the application of ET-1. (B) Similar experiment to that illustrated in A, except that the cell was superfused simultaneously with ET-1 (100 nM) and 2-APB (2 µM). (C) Average SCT frequencies for cells superfused with either ET-1 alone (black bars) or ET-1 + 2-APB (grey bars). (D,E) Similar experiments to those illustrated in A and B, except that the cells were stimulated with a membrane-permeant Ins(1,4,5)P₃ ester (2 µM) instead of ET-1. (F) Average SCT frequencies for cells superfused with either Ins(1,4,5)P₃ ester alone (black bars) or Ins(1,4,5)P₃ ester + 2-APB (grey bars). ^*P<0.05 (significantly different from control); calculated using Student's t-test).

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