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Fig. 3. Isoproterenol stimulates positive inotropy and SCTs in ventricular myocytes. (Ai-iv) Traces depict the effect of continuous superfusion of ventricular myocytes with isoproterenol (100 nM). The isoproterenol superfusion was initiated just after the trace in i was recorded. Arrows indicate field stimulation. (B) Normalised response (mean ± s.e.m.; n=12 cells) of ventricular myocytes to electrical pacing over a 25-minute period. ^*P<0.05; calculated using Student's t-test). (C) Montages of confocal images obtained from a single ventricular myocyte loaded with Fluo-4 either (i) before, (ii) 5 minutes after or 12.5 minutes (iii) after the start of superfusion with isoproterenol. The cell was field stimulated at the times indicated by the white arrows. N.B. In panel Cii, the initial image of the cell (i.e. at 0 milliseconds) shows elevated Ca²⁺ at the extreme ends of the cell. This reflects the final stage of a Ca²⁺ wave that had propagated horizontally throughout the myocyte. Bar, spatial scale of 15 µm.

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