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Figure 1


Fig. 1. Epithelial cells in intact salivary glands undergo dynamic movements. (A) Schematic diagram of an intact E13 SMG with epithelium (e) and surrounding mesenchyme (m); the box indicates the region imaged by time-lapse microscopy in panel B. (B) Epithelial buds with surrounding mesenchyme (top) imaged in supplementary material Movie 1 at t=0. The white dashed box indicates the region shown magnified below from individual frames of Movie 1. Two cells that move towards the right are outlined (red and cyan). (C) Schematic diagram indicating the site of Ad-GFP microinjection into epithelium; the box indicates the epithelial region shown in D. (D) First frame from a time-lapse movie showing brightfield-imaged (left) and GFP-labeled cells (right), revealing substantial apparent epithelial cell movements (supplementary material Movie 2). (E) Immunostaining of the microinjected gland after time-lapse analysis with the epithelial marker E-cadherin (red) indicated that the injected GFP-expressing cells (green) are epithelial (arrowheads). Time is indicated in hours:minutes. Bars, 20 µm.





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