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Figure 4


Fig. 4. Cbs concentrates in the pericentriolar region between centrosomes at cellularization. (A-D) At the start of cellularization immediately after centrosomes have replicated, Cbs concentrates on the apical surface of nuclei, filling the region between separated centrosomes and persists throughout cellularization. We detect low levels of colocalization between Cbs and Cnn (arrowheads B-D) and between Cbs and the ER at this stage. (E-H) The concentration of Cbs at the pericentriolar region persists in most cells during early gastrulation, lasting the longest in cells along segmental boundaries and embryonic furrows. There is weak colocalization between Cbs and the ER near nuclei (white in merged image). (I-L) By late gastrulation the levels of Cbs are reduced to multiple foci, randomly distributed throughout cells in close association with the most compact microtubule staining. There is no detectable colocalization between Cbs and the ER in these embryos. Embryos are immunostained as in Fig. 2. Bar, 10 µM.





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