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Figure 1


Fig. 1. Time lapse analysis of TN-R-induced microprocesses and enlarged growth cones. Tectal cells were cultivated on immobilized contactin 1, observed under time-lapse control, and phase-contrast images were taken before (upper panel), 2 hours after (middle panel) and 4 hours after (lower panel) the addition of TN-R (10 µg/ml). Bar, 10 µm. For evaluation of motility at a 1-minute interval, compare left with right image. Within a 4-hour observation period, TN-R stimulates the formation of large and motile growth cones and of highly dynamic microprocesses at the neurite shaft (arrows).





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