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Figure 6


Fig. 6. Effect of chronic hypoxia of 9 to 24 hours on HIF1{alpha} hydroxylation. Model results show the amount of hydroxylated [HIF1{alpha}] per [PHD2] for four different ratios of PHD2 synthesis rate to HIF1{alpha} synthesis rate relative to the maximum [HIF1{alpha}]hydroxylated[PHD2]. HIF1{alpha} synthesis is a function of [O2] and duration of hypoxia, whereas PHD2 synthesis is a function of [HIF1{alpha}] and duration of hypoxia. HIF1{alpha} accumulation begins at 4 hours, and measurable PHD2 synthesis follows at 8 hours.





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