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Figure 4


Fig. 4. Karyogamy in budding yeast. (A) Models for nuclear congression in budding yeast. (Left) Sliding cross-bridge model for nuclear congression. In this model, Kar3p-Cik1p slides MTs past one another and then depolymerization occurs at the SPBs. (Right) Plus end model for nuclear congression. MTs are linked at the plus end by Kar3p-Cik1p and then depolymerize, drawing both nuclei together for karyogamy. (B) MT dynamics in the wild type and karyogamy mutants. (Left) Wild-type MT dynamics during nuclear congression. (Middle) MT dynamics when nuclear orientation is defective. MTs grow and shrink the cytoplasm and rely on stochastic interactions to cross-link and perform nuclear congression. (Right) MT dynamics when cross-linking is defective. MTs undergo dynamic instability in the cytoplasm but never interact. A failure to undergo karyogamy does not block the zygotic bud from forming, resulting in the assembly of two mitotic spindles within the same cell.





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