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Figure 3


Fig. 3. FRAP analyses of SR45 and SR1/SRp34 movement in cells treated with inhibitors of transcription or protein kinases. (A-C,E-G) Subsets of confocal images of epidermal nuclei treated with actinomycin D (A) SR45 and (E) SR1/SRp34, staurosporine (B) SR45 and (F) SR1/SRp34), and control (C) SR45 and (G) SR1/SRp34. A defined area or speckle (marked by a circle or arrow, respectively) was imaged before and after bleaching. The entire data set of A-C was animated and is presented in Movie 5, supplementary material. (D,H) Recovery kinetics of SR45 (D) and SR1/SRp34 (H) in nuclei not treated (control) or treated with actinomycin D or staurosporine. Curves are averages of at least ten nuclei of two experiments. Error bars are ± s.e.m. (I) Diffusion coefficients of SR45 and SR1/SRp34 in control and treated cells. Values are the mean ± s.e.m. of at least ten cells.





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