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Fig. 3. Altered expression of cytokeratin markers in the epidermis of the bi-transgenics. Immunohistochemical staining of dorsal skin from E18.5 embryos with anti-keratin5, loricrin, anti-keratin1, anti-keratin17 or anti-keratin8 antibodies showing abnormal expression of keratin1, 8, 17 but normal compartmentalization of keratin5 and loricrin. Bar, 50 µm.